In general, the acyclic nucleoside of pyrazolo 3, 4 d pyrimidine derivative 42 revealed the highest anticancer activity among the other tested compounds. Alfa aesar is a leading manufacturer and supplier of research chemicals, pure metals and materials for a wide span of applications. In the title compound, c 19 h 16 n 4 s, the pyrazolo 3, 4 d pyrimidine ring is close to being planar, with the greatest deviation from the mean plane being 0. Simple and clean access to pyrazolo 3, 4 d thiazolo 3,2a pyrimidine derivatives using solvent free and hsbm techniques through the multicomponent reactio. Pdf synthesis of some novel pyrazolo3,4dpyrimidine. In fact, the antitumor effect of these novel pyrazolo 3, 4 d pyrimidine compounds is partly through augmenting ros stress by production of h 2 o 2.
Synthesis of some novel pyrazolo 3,4dpyrimidine derivatives article pdf available in archive for organic chemistry 200716 november 2007 with 197 reads how we measure reads. Note that from the first issue of 2016, mdpi journals use article numbers instead of page numbers. Generally pyrazolopyrimidine and its derivatives are found to possess a wide range of important pharmacophores and are privileged structures in medicinal chemistry. Novel purine and pyrazolo 3, 4 d pyrimidine inhibitors of pi3 kinase hit to lead studies.
Herein, we present the onepot twostep procedure for the synthesis of a set of pyrazolo 3, 4 d pyrimidine prodrugs 1a. The pyrazolo 3, 4 d pyrimidine derivative, sco201, reverses multidrug resistance mediated by abcg2bcrp. Despite the promising anticancer activity, these molecules showed a. Pyrazolo 3, 4 d pyrimidines are potent protein kinase inhibitors with promising antitumor activity but suboptimal aqueous solubility, consequently worth being further optimized. A series of pyrazolo 3, 4 d pyrimidine derivatives containing a schiff base moiety were synthesized, characterised, and evaluated for their activity against tobacco mosaic virus tmv. Multicomponent preparation of pyrazolo3,4dthiazolo3,2. Pyrazolo 3, 4 d pyrimidines as potent antiproliferative and proapoptotic agents toward a431 and 8701bc cells in culture via inhibition of csrc phosphorylation. Biological assays indicated that several of the derivatives exhibited significant activity against tmv. Pyrazolo3,4dpyrimidines are bicyclic heteroaromatic organic compounds in which the pyrazole ring is fused to the pyrimidine ring. Study of novel pyrazolo3,4dpyrimidine derivatives as.
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